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Differences of milk-transmitted murine mammary tumor virus (MMTV) among mouse strains
K Sayama1, Y Takeda, H Hashimoto
1Faculty of Agriculture, Department of Animal Science, Shizuoka University, Japan.
Abstract:
To clarify the oncological differences of milk-transmitted Murine Mammary Tumor Virus (MMTV) in various strains, BALB/c mice were foster-nursed on C3H/He, GR, DDD, DDD/1-Mtv-2/Mtv-2 and FM strains and observed for the development and morphology of mammary tumors, followed by testing tumors for pregnancy dependence (PD) after transplantation. MMTV were different in tumorigenicity and morphology and PD of induced tumors among the mouse strains. These differences of MMTV appeared not to be parallel with the difference in specificity of superantigens which are encoded by MMTV on the previous report. Interestingly, host factors influenced the properties of MMTV produced by the same endogenous Mtv gene.