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Absence of hyperactivity in lead-exposed developing rats.

D Krehbiel, G A Davis, L M LeRoy

Environmental Health Perspectives

|December 1, 1976

Summary

Postnatal lead exposure in rats did not cause hyperactivity. This study suggests that low-level lead exposure may not reliably induce hyperactivity in rodents, challenging previous findings.

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Area of Science:

Neuroscience
Toxicology
Developmental Psychology

Background:

Previous research suggested postnatal lead exposure causes hyperactivity in rodents.
A rodent model for childhood hyperactivity has been proposed based on lead exposure.

Purpose of the Study:

To investigate the effects of postnatal lead exposure on rodent behavior.
To assess the validity of lead-induced hyperactivity as a model for childhood hyperactivity.

Main Methods:

Offspring of lead-intubated and pair-fed control mothers were used.
Locomotor activity was measured in rats aged 24-27 days.
Behavioral observations were conducted at 28-29 and 35-36 days of age.
Brain lead concentrations were analyzed.

Main Results:

No significant differences in locomotor activity or basal activity were observed between lead-exposed and control rats.
Active behaviors were slightly reduced in lead-exposed rats.
Brain lead concentrations were significantly elevated in lead-exposed rats.
Statistical power analyses indicated that previously reported hyperactivity effects would likely have been detected.

Conclusions:

Low-level postnatal lead exposure may not reliably produce hyperactivity in rodents.
Existing data offer limited support for lead-induced hyperactivity in rodents as a model for childhood hyperactivity.

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