Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A genetic study on deaf twins.

Acta Geneticae Medicae Et Gemellologiae

|January 1, 1976

Summary

This summary is machine-generated.

Hearing loss concordance is high in identical twins (88%) but lower in fraternal twins (50%), indicating a strong genetic component. Consanguinity was significantly elevated in Japanese families with deafness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Structure of Porriolide, a New Metabolite from Alternaria porri.

Bioscience, biotechnology, and biochemistry·2016

Same author

Isolation and Identification of 6-(3',3'-Dimethylallyloxy)-4-methoxy-5-methylphthalide from Alternaria porri.

Bioscience, biotechnology, and biochemistry·2016

Same author

The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS.

Cell death & disease·2015

Same author

Peptidoglycan inhibits progesterone and androstenedione production in bovine ovarian theca cells.

Toxicology in vitro : an international journal published in association with BIBRA·2014

Same author

Relationship between aerobic endurance training and dynamic cerebral blood flow regulation in humans.

Scandinavian journal of medicine & science in sports·2013

Same author

Predominant involvement of the cerebellum in guinea pigs infected with bovine spongiform encephalopathy (BSE).

Journal of comparative pathology·2010

Same journal

Prevalence and forms of congenital anomalies in twins born in Pomeranian District during the period from 1.07.1997 to 31.12.1998. Polish Register of Congenital Anomalies.

Acta geneticae medicae et gemellologiae·2000

Same journal

Analysis of triple test results in 27 cases of twin pregnancies.

Acta geneticae medicae et gemellologiae·2000

Same journal

Long-term follow-up study of somatic development in prematurely born twins after life-threatening episodes.

Acta geneticae medicae et gemellologiae·2000

Same journal

Ultrasound in the diagnosis of twin-to-twin transfusion syndrome--a preliminary report.

Acta geneticae medicae et gemellologiae·2000

Same journal

Characteristics of adaptation period for extrauterine life of neonates from multiple pregnancies.

Acta geneticae medicae et gemellologiae·2000

Same journal

From the research on electrophoretical mobility of nuclei in twins.

Acta geneticae medicae et gemellologiae·2000

See all related articles

Area of Science:

Genetics
Otolaryngology
Twin Studies

Background:

Hearing loss is a common sensory impairment with complex etiology.
Twin studies are crucial for dissecting genetic and environmental contributions to complex traits.
Understanding the genetic basis of deafness is essential for diagnosis and intervention.

Purpose of the Study:

To investigate the concordance rate of hearing loss in monozygotic (MZ) and dizygotic (DZ) twins.
To assess the penetrance of genetic factors contributing to deafness.
To evaluate the prevalence of consanguinity in families with deaf members.

Main Methods:

A clinical and genetic study was conducted on 25 twin pairs where at least one twin had hearing loss.
Concordance rates for hearing loss were calculated for MZ and DZ twin pairs.

Related Experiment Videos

The prevalence of consanguinity was assessed and compared to the general population.

Main Results:

The concordance rate for hearing loss was 0.88 in MZ twins and 0.50 in DZ twins.
Genetic penetrance for hearing loss was found to be high (P = 0.94).
Consanguinity was present in 32% of cases, a five-fold increase compared to the Japanese population average.

Conclusions:

The high concordance in MZ twins and lower rate in DZ twins strongly suggests a significant genetic influence on hearing loss.
The findings highlight the importance of genetic factors and potentially recessive inheritance patterns in deafness.
The elevated consanguinity rate in affected families warrants further investigation into its role in the etiology of hearing loss in Japan.