Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital malformations in twins.

N C Myrianthopoulos

    Acta Geneticae Medicae Et Gemellologiae
    |January 1, 1976
    PubMed
    Summary

    Twin births show higher malformation rates than singletons, particularly in monozygotic (MZ) twins. Malformations affected various systems, with cotwins often exhibiting abnormalities too.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The philosophic origins of science and the evolution of the two cultures.

    Emerging infectious diseases·2000
    Same author

    New hereditary malformation syndrome of unusual facial appearance, skeletal deformities, and musculoskeletal and sensory defects.

    American journal of medical genetics·1992
    Same author

    Congenital anomalies: mortality and morbidity, burden and classification.

    American journal of medical genetics·1987
    Same author

    Studies in neural tube defects. I. Epidemiologic and etiologic aspects.

    American journal of medical genetics·1987
    Same author

    Studies in neural tube defects. II. Pathologic findings in a prospectively collected series of anencephalics.

    American journal of medical genetics·1987
    Same author

    Molecular approaches in the prenatal diagnosis and therapy of genetic disorders.

    Fetal therapy·1987

    Area of Science:

    • Medical Genetics
    • Developmental Biology
    • Epidemiology

    Background:

    • Congenital malformations represent a significant global health concern.
    • Understanding risk factors, such as twinning, is crucial for early detection and intervention.
    • Previous studies suggest potential differences in malformation rates between twins and singletons.

    Purpose of the Study:

    • To investigate the prevalence and patterns of congenital malformations in twins compared to singletons.
    • To identify specific systems affected by malformations in twins.
    • To explore the concordance of malformations within twin pairs.

    Main Methods:

    • Analysis of data from the Collaborative Perinatal Project.
    • Comparison of malformation frequencies between 1195 twins and a singleton cohort.
    • Categorization of malformations by type (single/multiple) and affected systems.

    Main Results:

    • Overall malformation rate in twins was 18.33%, significantly higher than singletons.
    • Monozygotic (MZ) twins accounted for the increased malformation frequency.
    • Malformations were more common in Negro and male twins, affecting central nervous, musculoskeletal, and cardiovascular systems.
    • Genitourinary and integumentary systems showed fewer malformations in twins.
    • Cotwin malformation concordance was observed in a significant number of cases.

    Conclusions:

    • Twinning, especially MZ twinning, is associated with an elevated risk of congenital malformations.
    • Specific demographic and systemic patterns of malformations exist in twins.
    • Further research into the etiology of twin malformations is warranted.

    Related Experiment Videos