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Updated: Sep 29, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Acute coronary syndromes: the clot is there

G C Timmis, H D White

    The American Journal of Cardiology
    |June 11, 1999
    PubMed

    Insights

    Thrombus plays a critical role in acute occlusive coronary artery disease, contrary to previous underestimations. Evidence confirms its significance in acute coronary syndromes, impacting treatment strategies.

    Area of Science:

    • Cardiology
    • Vascular Biology
    • Thrombosis Research

    Background:

    • Previous attempts to remove coronary artery clot underestimated thrombus prevalence and importance in acute coronary syndromes.
    • The role of thrombus in acute occlusive coronary artery disease has been historically underappreciated.

    Discussion:

    • Over 20 years of evidence, including successful reperfusion rates exceeding 80% with modern thrombolytic agents, confirms thrombus's critical role.
    • Achieving Thrombolysis In Myocardial Infarction trial grade 2 and 3 flow highlights the impact of thrombus on coronary artery patency.

    Key Insights:

    • Thrombus is a central pathophysiologic factor in acute coronary syndromes.
    • Effective reperfusion therapies underscore the significance of addressing thrombus in myocardial infarction.

    Outlook:

    • Future research should focus on refining thrombus detection and targeted therapies.
    • Understanding thrombus dynamics is essential for improving outcomes in acute occlusive coronary artery disease.

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