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Updated: Jul 11, 2026

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model
09:46

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model

Published on: September 14, 2009

Coronary artery stent restenosis responds favorably to repeat interventions

N Jolly1, S G Ellis, I Franco

  • 1Department of Cardiology, The Cleveland Clinic Foundation, Ohio, USA.

The American Journal of Cardiology
|June 11, 1999
PubMed

Insights

Predictors for repeat intervention after in-stent restenosis treatment include current smoking and graft location. Rotational atherectomy and repeat percutaneous transluminal coronary angioplasty (PTCA) showed similar target vessel revascularization rates.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Medicine

Background:

  • In-stent restenosis (ISR) is a significant complication following percutaneous coronary intervention.
  • Identifying predictors of reintervention and comparing treatment strategies for ISR is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the independent predictors of target vessel revascularization (TVR) in patients treated for ISR.
  • To compare the efficacy of rotational atherectomy versus repeat percutaneous transluminal coronary angioplasty (PTCA) for managing ISR.

Main Methods:

  • Retrospective evaluation of 160 patients who underwent percutaneous intervention for ISR.
  • Clinical follow-up to assess TVR rates.
  • Statistical analysis to identify independent predictors and compare treatment outcomes.

Main Results:

  • Current smoking and saphenous vein graft location were identified as independent predictors of TVR.
  • No significant difference in TVR rates was observed between rotational atherectomy and repeat PTCA.
  • Both treatment modalities demonstrated comparable effectiveness in managing ISR.

Conclusions:

  • Smoking cessation and careful consideration of graft location are important for patients with ISR.
  • Rotational atherectomy and repeat PTCA are both viable options for treating ISR, with similar reintervention rates.

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