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Yellow nails and minimal change nephrotic syndrome
S Yáñez1, J F Val-Bernal, H Fernández-Llaca
1Dermatology Service, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.
Nephron
|June 12, 1999
Summary
This study details a rare case of yellow nail syndrome (YNS) linked with minimal change nephrotic syndrome (MCNS) in a 38-year-old man. Treatment led to MCNS resolution and YNS improvement, highlighting a novel association.
Area of Science:
- Nephrology
- Dermatology
Background:
- Yellow nail syndrome (YNS) is a rare disorder characterized by yellowing and thickening of the nails, often accompanied by lymphedema and respiratory issues.
- Minimal change nephrotic syndrome (MCNS) is a common cause of nephrotic syndrome in children and adults, characterized by normal-appearing glomeruli under light microscopy.
Observation:
- A 38-year-old male presented with symptoms indicative of both yellow nail syndrome and minimal change nephrotic syndrome.
- The patient exhibited characteristic nail changes and nephrotic-range proteinuria.
Findings:
- This case represents the first documented association between yellow nail syndrome and minimal change nephrotic syndrome.
- Treatment with prednisone effectively resolved the nephrotic syndrome, while vitamin E supplementation showed a slow but positive impact on the yellow nail changes.
Implications:
- This finding expands the known clinical spectrum of yellow nail syndrome and its potential systemic associations.
- Further research is warranted to elucidate the underlying pathomechanisms connecting these two conditions and to optimize treatment strategies for co-occurring YNS and MCNS.