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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
The lung in the immunocompromised patient. Infectious complications part 2
1Division of Pneumology, University Hospital Basel, Switzerland. michaelt@mailmed.usyd.edu.au
Abstract:
Pulmonary infections decisively contribute to morbidity and mortality in immunocompromised patients. Bacterial, mycobacterial and infections with Pneumocystis carinii have been reviewed in an article in the last issue of Respiration. In this review, viral and fungal pulmonary infections are discussed in HIV-positive patients and in patients treated with high-dose chemotherapy, stem cell or solid-organ transplantation.
Insights
This review covers viral and fungal pulmonary infections in immunocompromised patients, focusing on those with HIV or undergoing transplantation. It highlights key pathogens and their impact on patient health.
Area of Science:
- Infectious Diseases
- Pulmonology
- Immunology
Background:
- Pulmonary infections are a major cause of illness and death in immunocompromised individuals.
- Previous reviews covered bacterial, mycobacterial, and Pneumocystis carinii infections.
Purpose of the Study:
- To review viral and fungal pulmonary infections in specific immunocompromised patient groups.
- To provide an overview of current knowledge on these infections.
Main Methods:
- Literature review of viral and fungal pulmonary infections.
- Focus on patients with Human Immunodeficiency Virus (HIV).
- Focus on patients undergoing high-dose chemotherapy, stem cell, or solid-organ transplantation.
Main Results:
- Viral infections pose significant risks in immunocompromised hosts.
- Fungal infections are also a critical concern in these populations.
- Specific pathogens and their clinical significance are discussed.
Conclusions:
- Viral and fungal pulmonary infections require careful management in immunocompromised patients.
- Early diagnosis and treatment are crucial for improving outcomes.
- This review complements previous discussions on other pulmonary pathogens.
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