[Tissue plasminogen activator as a prognostic factor in myocardial infarct patients]

Changes in hemostasis inducing hypercoagulability are pathogenic factors for the development of ischemic heart disease and myocardial infarction. Nevertheless, their role is unknown in the emergence of new coronary events in patients with infarction. A group of 58 patients who had survived to a first infarction episode were studied; the cardiovascular risk factors were determined and blood concentrations of fibrinogen, t-PA, PAI and FRW measured. These patients were followed for two years to observe the development of new ischemic problems. In the study only the t-PA concentration was found to be a factor for poor prognosis.