Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiologic consequences of pneumonectomy. Consequences on the pulmonary function.

F Tronc1, J Grégoire, P Leblanc

  • 1Division of Thoracic Surgery, Centre de pneumologie de L'Hôpital Laval, Sainte-Foy, Quebec, Canada.

Chest Surgery Clinics of North America
|June 12, 1999
PubMed
Summary

Children may experience lung growth after pneumonectomy, unlike adults whose lung volume response is limited. This review explores the physiological mechanisms behind compensatory lung growth following pneumonectomy in both humans and animals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of lung transplantation for pleuroparenchymal fibroelastosis: A French multicentric retrospective study.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2024
Same author

The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways.

BMC biology·2021
Same author

Sentinel lymph node (SLN) isolated tumor cells (ITCs) in otherwise stage I/II endometrioid endometrial cancer: To treat or not to treat?

Gynecologic oncology·2021
Same author

[Short-term results of video-assisted lung cancer surgery in octogenarians].

Revue des maladies respiratoires·2020
Same author

Effects of High-Intensity Interval Running Versus Cycling on Sclerostin, and Markers of Bone Turnover and Oxidative Stress in Young Men.

Calcified tissue international·2019
Same author

Transcatheter aortic valve implantation: a safe and efficient procedure to treat an aortic valve stenosis before lung cancer resection.

General thoracic and cardiovascular surgery·2018

Area of Science:

  • Pediatric Pulmonology
  • Thoracic Surgery
  • Respiratory Physiology

Background:

  • Pneumonectomy, the surgical removal of a lung, raises questions about compensatory lung growth.
  • Adults show limited lung volume response post-pneumonectomy, primarily due to alveolar distention, not multiplication.
  • Mechanical stretch is considered a key initiator of compensatory growth.

Purpose of the Study:

  • To review the physiological adjustments following pneumonectomy.
  • To investigate the potential for lung growth in pediatric patients after pneumonectomy.
  • To discuss the mechanisms and mediators of adaptive lung responses.

Main Methods:

  • Review of existing human observational data.
  • Analysis of experimental findings in animal models.

Related Experiment Videos

  • Discussion of physiological mechanisms and mediators.

    • Main Results:

    • Adult compensatory lung growth is incomplete, characterized by alveolar distention.
    • Stretch is a primary stimulus for compensatory growth.
    • The review synthesizes data on human and animal responses to pneumonectomy.

    Conclusions:

    • Pneumonectomy elicits complex physiological adaptations.
    • Further research is needed to fully understand pediatric lung growth post-pneumonectomy.
    • Mechanisms of compensatory lung growth involve various mediators and cellular responses.