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Related Experiment Videos

Destructive bone disease in early syphilis.

W E Dismukes, D G Delgado, S V Mallernee

    JAMA
    |December 6, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Early syphilis can cause bone infections like osteomyelitis, which is often overlooked. This case highlights secondary syphilis presenting with bone lesions, successfully treated with penicillin.

    Area of Science:

    • Infectious Diseases
    • Bone Pathology
    • Syphilology

    Background:

    • Tertiary syphilis is known for causing destructive bone disease.
    • Osteitis and osteomyelitis are rarely recognized complications of early syphilis (primary or secondary).

    Observation:

    • A patient presented with symptoms of secondary syphilis, including generalized lymphadenopathy, perianal condyloma lata, and positive serological tests (Rapid Plasma Reagin and Fluorescent Treponemal Antibody-Absorption).
    • The patient also reported headache, right shoulder pain, and right anterior chest pain and swelling.

    Findings:

    • Radiographic imaging revealed mottled osteolytic lesions, indicative of luetic bone disease.
    • A biopsy confirmed the diagnosis of syphilitic osteomyelitis.

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    Implications:

    • This case underscores that early syphilis can manifest with bone involvement, specifically osteomyelitis.
    • Prompt diagnosis and penicillin treatment are effective in resolving syphilitic osteomyelitis and associated symptoms.