[The influence of angiotensin converting enzyme inhibitors on the central nervous system]

Angiotensin converting enzyme inhibitors (ACEI) constitute 23% of all antihypertensive drugs world-wide (WHL Newsletter, October 1997). Although lipophilic ACEIs like captopril, trandolapril or perindopril may decrease blood pressure partly via central nervous system (CNS) they also are capable of evoking a range of psychotropic effects. Basing on our recent experiments and the literature data we discussed possible effects of ACEIs on mood and cognition.