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Published on: May 12, 2011
Giant cell angiofibroma of the orbit and eyelid
N Hayashi1, G Borodic, J W Karesh
1Wilmer Ophthalmological Institute, and Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Purpose:
To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma.
Design:
Observational case series.
Main Outcome Measures:
Clinical and histopathologic features of giant cell angiofibroma.
Methods:
Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma.
Results:
A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin.
Conclusion:
Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.
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