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Surgical experience with hepatic colorectal metastasis
A L Bradley1, W C Chapman, J K Wright
1Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee 37232-4753, USA.
The American Surgeon
|June 12, 1999
Summary
Hepatic resection for colorectal metastasis offers the best survival outcomes for selected patients. Survival rates at 5 years were 36%, with repeat resections showing 74% survival.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Colorectal Cancer Management
Background:
- Colorectal metastasis frequently involves the liver, necessitating effective treatment strategies.
- Hepatic resection is a primary therapeutic option for resectable liver metastases.
- Evaluating long-term outcomes is crucial for optimizing patient selection and treatment protocols.
Purpose of the Study:
- To analyze the long-term outcomes of hepatic resection in patients with colorectal metastasis.
- To identify prognostic factors influencing survival after liver resection for colorectal cancer.
- To assess the efficacy of repeat hepatic resections for recurrent disease.
Main Methods:
- Retrospective analysis of 134 patients undergoing hepatic resection for colorectal metastasis.
- Detailed review of patient demographics, surgical data, pathology, and follow-up information.
- Kaplan-Meier survival analysis and assessment of prognostic variables.
Main Results:
- Overall 5-year survival was 36%, with 10-year survival at 19%.
- Survival was significantly better for patients with 1-4 lesions compared to 5+ lesions (P < 0.01).
- Repeat hepatic resections in 15 patients yielded a 5-year survival of 74%.
Conclusions:
- Hepatic resection is the optimal treatment for selected patients with isolated colorectal liver metastases.
- The number of liver lesions is a critical prognostic factor.
- Repeat hepatic resections can achieve excellent long-term survival in select patients.