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Urinary gonadotropin peptide as acute phase reactant: transient elevation after operation for digestive diseases
1Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
European Journal of Endocrinology
|June 12, 1999
Summary
Urinary gonadotropin peptide (UGP) levels increase temporarily after surgery, suggesting it acts as an acute phase reactant. UGP elevation correlates with surgical stress and inflammatory markers like IL-6.
Area of Science:
- Biochemistry
- Immunology
- Surgical Oncology
Background:
- Urinary gonadotropin peptide (UGP) is a molecule of interest in physiological studies.
- Its role as an acute phase reactant has not been fully characterized.
Purpose of the Study:
- To investigate urinary gonadotropin peptide (UGP) levels following surgical procedures.
- To determine if UGP functions as an acute phase reactant.
Main Methods:
- Enzyme immunoassay was used to measure UGP levels.
- Measurements were taken before and after surgery in patients undergoing gastrointestinal cancer surgery or other procedures.
- Urinary interleukin (IL)-6 and luteinizing hormone (LH) levels were also monitored.
Main Results:
- Transient elevations in UGP were observed in 80.6% of the 67 cases studied.
- Urinary IL-6 and LH also showed transient increases in 73.1% of cases.
- UGP levels correlated with IL-6 and LH, with a consistent peak order: IL-6, LH, then UGP.
- Higher UGP levels were noted after total gastrectomy compared to partial gastrectomy.
Conclusions:
- UGP exhibits a transient peak post-surgery, indicating a potential role as an acute phase reactant.
- UGP levels appear to correlate with the intensity of surgical stress and inflammatory responses.
- These findings suggest UGP could serve as a biomarker for surgical stress.