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Related Experiment Videos

The Ca-calmodulin-dependent protein kinase cascade.

T R Soderling1

  • 1Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA. soderlit@ohsu.edu

Trends in Biochemical Sciences
|June 15, 1999
PubMed
Summary
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Cellular signaling through multifunctional Ca2+/calmodulin-dependent protein kinase II.

The Journal of biological chemistry·2000

The Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade, abundant in brain and T cells, responds to calcium signaling. This cascade, involving CaMKK, CaMKI, and CaMKIV, plays roles in nuclear transcription and neuronal survival.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Neuroscience

Background:

  • The Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade comprises CaM-kinase kinase (CaMKK), CaMKI, and CaMKIV.
  • This signaling pathway is activated by elevated intracellular Ca2+ levels and is prevalent in brain and T cells.

Purpose of the Study:

  • To elucidate the roles and interactions within the CaM kinase cascade.
  • To understand the localization and functions of CaMKK, CaMKI, and CaMKIV in cellular processes.

Main Methods:

  • The study describes the components and localization of the CaM kinase cascade.
  • It details the cross-talk with other signaling pathways like PKA, MAP kinases, and PKB/Akt.

Main Results:

Related Experiment Videos

  • CaMKK activates CaMKI and CaMKIV. CaMKK and CaMKIV are found in both nucleus and cytoplasm, while CaMKI is cytosolic.
  • Nuclear CaMKIV regulates transcription via transcription factors like CREB.
  • Cytoplasmic CaMKK, CaMKIV interact with PKA, MAP kinases, and PKB/Akt.

    • Conclusions:

    • The CaM kinase cascade is a key regulator of cellular responses to calcium.
    • Activation of protein kinase B (PKB/Akt) by CaMKK is crucial for neuronal survival during development.