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Transforming growth factor beta in infectious disease: always there for the host and the pathogen
D R Fitzpatrick1, H Bielefeldt-Ohmann
1Leukocyte Biology Unit of the Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia.
Trends in Microbiology
|June 15, 1999
Abstract:
At the portals of pathogen entry, there are pools of the latent form of a potent cytokine, transforming growth factor beta (TGF-beta). Many infections activate these pools and stimulate further TGF-beta expression. As well as potent immunomodulation, activated TGF-beta might have important effects on pathogen entry, replication, persistence, latency and oncogenesis.