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Urinary calcium in perimenopausal women: normative values
R P Heaney1, R R Recker, R A Ryan
1Creighton University, Omaha, Nebraska 68131, USA.
Summary
Urinary calcium excretion in perimenopausal women varies with estrogen levels and dietary calcium. This study establishes normal ranges for urinary calcium in estrogen-replete and estrogen-deprived states, crucial for understanding bone health.
Area of Science:
- Endocrinology
- Mineral Metabolism
- Women's Health
Background:
- Perimenopausal transition is associated with hormonal fluctuations impacting mineral balance.
- Urinary calcium excretion is a key indicator of calcium homeostasis and bone health.
- Understanding normal ranges is essential for clinical assessment.
Purpose of the Study:
- To determine the normal range of 24-hour urinary calcium excretion in perimenopausal women.
- To investigate the influence of estrogen status on urinary calcium levels.
- To assess the effect of varying dietary calcium intake on urinary calcium excretion.
Main Methods:
- Controlled dietary and metabolic balance studies were conducted.
- 24-hour urinary calcium was measured in 191 normal perimenopausal women.
- Data were collected at 5-year intervals across different estrogen and calcium intake conditions.
Main Results:
- A comprehensive dataset of 586 urinary calcium values was generated.
- Normal ranges for urinary calcium excretion were defined for estrogen-replete states.
- Normal ranges were also established for estrogen-deprived states and varying calcium intakes.
Conclusions:
- Estrogen status significantly influences urinary calcium excretion in perimenopausal women.
- Dietary calcium intake modulates urinary calcium levels within normal ranges.
- These findings provide critical reference values for clinical and research applications in women's health.