[Animal experimental studies on the pharmacokinetics of "essential" phospholipids (EPL)]

The pharmacokinetics of orally applied "essential" phospholipids (EPL) (i.e. polyenyl phosphatidyl choline) was investigated in conscious and in anesthetized rats with the aid of radioactively labelled dilinolyl phosphatidylcholines (3H and 14C.). Absorption, distribution and metabolism of EPL were studied using autoradiography and by measuring the distribution of the abosrbed radioactivity in lymph, blood and internal organs, and by determining excretion and expiration.