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Branched chain amino acids decrease tardive dyskinesia symptoms.

M A Richardson1, M L Bevans, J B Weber

  • 1Movement Disorders Division, The Nathan S. Kline Institute for Psychiatric Research, New York State Office of Mental Health, Orangeburg 10962, USA.

Psychopharmacology
|June 15, 1999
PubMed
Summary
This summary is machine-generated.

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Increasing intake of branched-chain amino acids (BCAA) significantly reduced tardive dyskinesia (TD) symptoms in men. This suggests BCAA may be a promising treatment for TD by improving amino acid balance in the brain.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Pharmacology

Background:

  • Tardive dyskinesia (TD) is associated with impaired clearance of phenylalanine (Phe).
  • Increased availability of branched-chain amino acids (BCAA) and reduced brain Phe levels may decrease TD symptoms.

Purpose of the Study:

  • To investigate if increasing daily BCAA intake can reduce TD symptoms.
  • To assess the impact of BCAA supplementation on plasma amino acid levels in patients with TD.

Main Methods:

  • A 2-week trial involving nine men with histories of neuroleptic treatment.
  • Administration of a BCAA medical food three times daily.
  • Videotape analysis of TD movement frequency and blind assessment of symptom changes.
  • Monitoring of plasma large neutral amino acid (LNAA) levels.

Related Experiment Videos

Main Results:

  • A statistically significant and clinically meaningful decrease in TD symptom severity was observed.
  • Six out of nine subjects experienced at least a 58% reduction in TD symptoms.
  • BCAA administration elevated plasma BCAA concentrations and BCAA/LNAA ratios, while decreasing Phe concentrations and Phe/LNAA ratios.
  • A strong correlation was found between increased plasma BCAA levels and TD symptom improvement.

Conclusions:

  • Branched-chain amino acids (BCAA) show potential as an effective treatment for tardive dyskinesia (TD).
  • BCAA treatment may alleviate TD symptoms by enhancing BCAA availability and reducing phenylalanine (Phe) availability to the brain.