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Related Experiment Videos

Interleukin-12 in human milk.

D L Bryan1, J S Hawkes, R A Gibson

  • 1Child Nutrition Research Centre, Flinders University of South Australia, Australia.

Pediatric Research
|June 15, 1999
PubMed
Summary
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Interleukin-12 (IL-12) was found in human milk samples. Concentrations varied, with higher levels in early milk and a decrease over time postpartum.

Area of Science:

  • Immunology
  • Human Lactation Research
  • Neonatal Nutrition

Background:

  • Interleukin-12 (IL-12) is a cytokine with critical roles in immune regulation.
  • Human milk is a complex biological fluid containing various bioactive components essential for infant development.
  • Understanding the immunological factors in human milk is crucial for infant health and development.

Purpose of the Study:

  • To investigate the presence and concentration of Interleukin-12 (IL-12) in human milk.
  • To analyze IL-12 levels across different stages of lactation (colostrum, transitional, and mature milk).
  • To determine if IL-12 concentration changes postpartum.

Main Methods:

  • Human milk samples (n=39) were collected from mothers.
  • The enzyme-linked immunosorbent assay (ELISA) was employed to quantify IL-12.

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  • IL-12 concentrations were measured in pg/mL.

    • Main Results:

    • Interleukin-12 (IL-12) was detected in 24 out of 39 human milk samples.
    • Detected IL-12 levels ranged from >40 pg/mL, with a mean concentration of 1408 +/- 2256 pg/mL.
    • A trend of decreasing mean IL-12 concentration was observed from colostrum to mature milk over time postpartum.

    Conclusions:

    • Interleukin-12 (IL-12) is present in human milk.
    • IL-12 levels exhibit variability throughout lactation, suggesting dynamic changes postpartum.
    • These findings contribute to the understanding of immunological components in human milk and their potential role in infant immunity.