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[Microaggregates in preserved blood].

M Frey-Wettstein, R Hoppler

    Schweizerische Medizinische Wochenschrift
    |October 16, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Microaggregates in stored blood can harm the lungs during massive transfusions. Using microaggregate-free blood products like fresh blood or specific red cell concentrates can prevent these pulmonary complications without needing expensive filters.

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    Area of Science:

    • Transfusion Medicine
    • Hematology
    • Pulmonary Circulation

    Background:

    • Stored blood contains microaggregates that pose risks to the pulmonary circulation.
    • Massive transfusions increase the likelihood of microaggregate-related complications.
    • Existing microaggregate filters are costly and their efficacy is not fully established.

    Purpose of the Study:

    • To evaluate the risks associated with microaggregates in transfused blood.
    • To explore alternatives to microaggregate filtration for preventing transfusion complications.
    • To identify microaggregate-free blood products suitable for massive transfusions.

    Main Methods:

    • Review of existing literature on blood storage and microaggregate formation.
    • Analysis of the pulmonary effects of transfused microaggregates.

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  • Identification and characterization of microaggregate-free blood components.

    • Main Results:

    • Microaggregates in stored blood are detrimental to pulmonary circulation in massive transfusion scenarios.
    • Microaggregate filters, while effective, present cost and validation challenges.
    • Fresh blood, fresh frozen plasma, and buffy-coat-free red cell concentrates are essentially free of microaggregates.

    Conclusions:

    • Preventing microaggregate exposure is crucial for managing massively transfused patients.
    • Utilizing microaggregate-free blood products offers a safe and cost-effective alternative to filtration.
    • Fresh blood components can be transfused in large volumes without filtration to avoid pulmonary complications.