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Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic
1First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Japan. misobe.os1@dent.tmd.ac.jp
Purpose:
This study examines the effect of polymer capsules containing recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone regeneration in a large segmental bone defect in the rat.
Materials And Methods:
Poly(DL-lactide-co-glycolide) (PLGA) capsules containing 3 microg of rhBMP-2 were implanted in a 5-mm segmental femoral defect in rats, and the femurs were harvested at 4 and 8 weeks after implantation and observed by radiographically and microscopically.
Results:
At 8 weeks after implantation, union of bone was found radiographically and histologically in the femoral defects implanted with the rhBMP-2/PLGA capsules. In contrast, the control animals did not show bridging of the defect.
Conclusions:
This study provides evidence that use of rhBMP-2/PLGA capsules is a promising delivery system to regenerate bone.