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Related Experiment Videos

Changing trends in prostatic cancer.

M Murphy1, C Johnston, P Whelan

  • 1Pyrah Department of Urology, St James's University Hospital, Leeds, UK.

BJU International
|June 15, 1999
PubMed
Summary
This summary is machine-generated.

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Prostate cancer incidence significantly increased before PSA testing, with higher mortality and metastasis rates. Survival rates in Yorkshire lagged behind other countries.

Area of Science:

  • Oncology
  • Epidemiology
  • Urology

Background:

  • Prostate cancer diagnosis and treatment patterns prior to widespread prostate-specific antigen (PSA) testing are crucial for understanding historical incidence trends.
  • Population-based studies are essential for evaluating cancer incidence and survival in specific geographic regions.

Purpose of the Study:

  • To investigate prostate cancer incidence and survival trends in Yorkshire during the decade preceding PSA testing.
  • To determine if the overall incidence of prostate cancer was increasing before the introduction of PSA screening.

Main Methods:

  • A population-based study of all men diagnosed with prostate cancer in Yorkshire between 1981 and 1990.
  • Data validation through histopathology reports and case-note review by the Northern and Yorkshire Cancer Registry.

Related Experiment Videos

  • Analysis of incidence, mortality, metastasis rates, and survival, stratified by age groups.

    • Main Results:

    • A 30% increase in age-standardized prostate cancer incidence and a 35% increase in mortality were observed during the study period.
    • The proportion of patients diagnosed with metastases at presentation rose from 18% to 24%.
    • Five-year and ten-year relative survival rates were 49% and 34%, respectively.

    Conclusions:

    • A genuine increase in prostate cancer incidence occurred before the widespread adoption of PSA testing.
    • Prostate cancer survival rates in Yorkshire during this period were comparable to other UK regions but lower than in other countries.