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Related Experiment Videos

Platelet aggregation following defibrination with ancrod.

C L Slade, W A Andes, A D Mason

    Thrombosis and Haemostasis
    |December 10, 1976
    PubMed
    Summary
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    Platelet aggregation in dogs was significantly inhibited after defibrination with Ancrod, showing a gradual recovery over 96 hours. This aggregation was independent of fibrinogen levels, correlating inversely with fibrin degradation products.

    Area of Science:

    • Hemostasis and Thrombosis
    • Pharmacology
    • Veterinary Medicine

    Background:

    • Ancrod is a defibrinogenating agent.
    • Platelet aggregation is crucial for hemostasis.
    • Understanding defibrination effects on platelet function is important.

    Purpose of the Study:

    • To investigate in vitro platelet aggregation in dogs after Ancrod-induced defibrination.
    • To assess the recovery of platelet aggregation over time.
    • To determine the relationship between platelet aggregation, fibrinogen levels, and fibrin degradation products.

    Main Methods:

    • Defibrination of canine blood using Ancrod.
    • In vitro measurement of platelet aggregation.
    • Quantification of fibrinogen and fibrin degradation products.

    Related Experiment Videos

  • Monitoring aggregation and related factors over 96 hours.

    • Main Results:

    • Immediate and marked inhibition of platelet aggregation post-defibrination.
    • Gradual but incomplete recovery of aggregation over 96 hours.
    • Platelet aggregation was independent of fibrinogen levels.
    • Significant inverse correlation between aggregation and fibrin degradation product levels.

    Conclusions:

    • Ancrod-induced defibrination profoundly affects platelet aggregation in dogs.
    • Platelet aggregation recovery is prolonged and incomplete within 96 hours.
    • Fibrinogen concentration is not the primary determinant of aggregation in this defibrinogenated state.