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Antioxidant activity of michellamine alkaloids
E L White1, L J Ross, P D Hobbs
1Biochemistry Department, Southern Research Institute, Birmingham, AL 35205, USA. white@sri.org
Anticancer Research
|June 16, 1999
Abstract:
The alkaloids michellamines A, B, and C are natural products isolated from a Central African tropical plant Ancistrocladus korupensis. We have investigated the radical scavenging ability of these compounds. The alkaloids inhibited the azo-induced oxidation of beta-phycoerythrin with IC50 values in the 0.5- to 0.8-microM range. Michellamine B also protected rat liver mitochondria against lipid peroxidation induced by adenosine diphosphate and Fe2+. The alkaloids were more potent antioxidants in these assays than several compounds being considered clinically as chemoprevention agents.