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Related Experiment Videos

[Drug induced alopecia].

P M van den Bemt1, C C Brodie-Meijer, R M Krijnen

  • 1Ziekenhuisapotheek Medisch Centrum Leeuwarden/Apotheek Ziekenhuis De Tjongerschans Heerenveen.

Nederlands Tijdschrift Voor Geneeskunde
|June 16, 1999
PubMed
Summary

Drug-induced alopecia, or hair loss, can occur when medications affect hair follicle cycles. Proving a direct link between a drug and hair loss is challenging due to multiple potential causes.

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Area of Science:

  • Dermatology
  • Pharmacology

Context:

  • Hair follicles exhibit cyclic activity: anagen (growth), catagen (transitional), and telogen (resting).
  • Alopecia is defined as the loss of over 120 hairs daily.
  • Drug-induced alopecia is typically diffuse and reversible, impacting hair follicle cycles.

Purpose:

  • To review the principal drug categories associated with alopecia.
  • To highlight reported cases of alopecia linked to specific medications.

Summary:

  • Commonly implicated drug classes include cytostatics, anticoagulants, interferons, retinoid derivatives, and lithium carbonate.
  • The Netherlands Pharmacovigilance Foundation LAREB has documented alopecia as a side effect of antimalarials, beta-blockers, sex hormones, ACE inhibitors, angiotensin II antagonists, and anticoagulants.
  • Establishing a definitive causal relationship between a drug and hair loss can be difficult due to multifactorial etiologies.

Impact:

  • Informs healthcare professionals about potential drug-induced hair loss.
  • Aids in diagnosing and managing alopecia by considering medication side effects.
  • Contributes to pharmacovigilance by documenting adverse drug reactions.

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