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Eye-tracking dysfunction and birth-month weather in schizophrenia.
D K Kinney1, D L Levy, D A Yurgelun-Todd
1Genetics Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA.
Eye-tracking dysfunction (ETD) is common in schizophrenia patients and relatives, indicating a genetic risk. Patients without ETD were more likely to be born during extreme weather, suggesting environmental factors contribute to non-familial schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Environmental Health
Background:
- Eye-tracking dysfunction (ETD) is prevalent in schizophrenia and relatives, suggesting a familial risk factor.
- Birth during intemperate weather is a known risk factor for schizophrenia, especially in those without a family history.
Purpose of the Study:
- To investigate the covariation between eye-tracking dysfunction and birth-month weather in schizophrenia patients.
- To explore the roles of familial (genetic) and environmental risk factors in schizophrenia etiology.
Main Methods:
- Assessed eye-tracking and birth-month weather independently in 78 schizophrenia patients.
- Compared risk factor prevalence between patients with and without ETD, and with the general population.
Main Results:
- Patients without ETD were significantly more likely to be born in months with intemperate weather (hot or cold).
- This finding contrasts with patients with ETD and the general population.
Conclusions:
- Environmental factors associated with severe weather around birth may contribute significantly to non-familial schizophrenia.
- ETD may represent a familial (genetic) risk factor, while extreme weather may indicate environmental influences.
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