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Updated: Aug 14, 2026
Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
Published on: December 7, 2011
Bone mineral density differences between paraplegic and quadriplegic patients: a cross-sectional study
1Department of Epidemiology, National Institute for Longevity Sciences, Aichi, Japan.
Study Design:
This cross-sectional study was conducted by comparing bone mineral density (BMD) of paraplegic and quadriplegic patients.
Objectives:
The purpose of this study was to investigate the relationship between the bone mineral loss and injury level in spinal cord injury patients.
Settings:
Experiments were conducted at Yoneda Hospital and Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
Methods:
Lumbar spine (L2-4), proximal femur (femoral neck, trochanter region and Ward's triangle) and whole body BMD were measured in ten paraplegic and ten quadriplegic patients using dual-energy X-ray absorptiometry (DXA, HITACHI BMD-IX).
Results:
Significant differences were observed in the lumbar spine, trochanter region and upper extremities BMD between paraplegic and quadriplegic patients (P<0.05, P<0.05 and P<0.01, respectively), but not in the femoral neck, Ward's triangle, head, pelvis, lower extremities or whole body BMD.
Conclusion:
These results suggest that the injury level influences on the lumbar spine, upper extremities and trochanter region BMD. From a biomechanical standpoint, it is possible to explain that the differences in mechanical loading exerted on bones also affected the difference of lumbar spine BMD in the two groups.
