Effects of cinepazide, a new vasoactive substance, on heart and circulation in the dog

The authors report on the action of a new drug, 1-(pyrrolidinyl-1-carbonyl)-methyl-4-(3,4,5-trimethoxycinnamoyl)-piperazine-maleate (cinepazide), on the heart and systemic and coronary circulation. At doses of 1--3 mg/kg i.v. (n=6), systemic blood pressure decreased by 4%, and heart rate increased reflexly by 8%...