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Once-daily aminoglycosides in the treatment of gram-positive endocarditis

V H Tam1, S L Preston, L L Briceland

  • 1Albany College of Pharmacy, NY 12208, USA.

The Annals of Pharmacotherapy
|June 16, 1999
PubMed
Abstract

Insights

Once-daily aminoglycosides (ODA) show potential for treating gram-positive endocarditis, but more research is needed. Current data is limited, and routine use is not yet recommended.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Gram-positive endocarditis is a serious infection.
  • Aminoglycosides are a class of antibiotics used in treatment.
  • Conventional dosing strategies exist for aminoglycoside therapy.

Purpose of the Study:

  • To evaluate the efficacy and safety of once-daily aminoglycosides (ODA) for gram-positive endocarditis.
  • To review existing literature on ODA in endocarditis treatment.

Main Methods:

  • Conducted a comprehensive literature search (MEDLINE, Current Contents) from 1984 to 1998.
  • Included English-language studies: animal, human, in vitro, and reviews.
  • Cross-referenced articles for additional relevant data.

Main Results:

  • ODA presents a theoretical alternative to conventional aminoglycoside dosing for endocarditis.
  • Limited clinical data currently supports ODA's advantages in efficacy, toxicity, or cost.
  • Optimal monitoring strategies for ODA remain undefined.

Conclusions:

  • Routine use of ODA for endocarditis is not currently advised.
  • Further well-designed clinical trials are warranted to establish the role of ODA in gram-positive endocarditis therapy.

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