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Updated: Jul 6, 2026
Orthotopic Small Bowel Transplantation in Rats
Published on: November 6, 2012
Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats
J P Buts1, N De Keyser, S Marandi
1Laboratory of Paediatric Gastroenterology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium.
Background:
Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa.
Aims:
To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats.
Methods:
Wistar rats, aged eight weeks, underwent 60% proximal resection or transection and received by orogastric intubation either 1 mg/g body wt per day lyophilised S boulardii or the vehicle for seven days. The effects on ileal mucosal adaptation were assessed eight days after surgery.
Results:
Compared with transection, resection resulted in mucosal hyperplasia with significant decreases in the specific and total activities of sucrase, lactase, and maltase. Treatment of resected animals with S boulardii had no effect on mucosal hyperplasia but did upgrade disaccharidase activities to the levels of the transected group. Enzyme stimulation by S boulardii was associated with significant increases in diamine oxidase activity and mucosal polyamine concentrations. Likewise, sodium dependent D-glucose uptake by brush border membrane vesicles, measured as a function of time and glucose concentration in the incubation medium, was significantly (p<0.05) increased by 81% and three times respectively in the resected group treated with S boulardii. In agreement with this, expression of the sodium/glucose cotransporter-1 in brush border membranes of resected rats treated with S boulardii was enhanced twofold compared with resected controls.
Conclusion:
Oral administration of S boulardii soon after proximal enterectomy improves functional adaptation of the remnant ileum.
