Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medulloblastoma - late outcome.

Todd1, Ruge

  • 1Department of Pediatrics, Lutheran General Children's Hospital, Park Ridge, IL 60068, USA

Critical Reviews in Neurosurgery : CR
|November 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Typhus Fever, Treated by Brandy, &c.

Iowa medical journal·2023
Same author

Development of adjuvant-active nonionic block copolymers.

Advanced drug delivery reviews·2000
Same author

Toxicity Screening of a Combinatorial Library: Correlation of Cytotoxicity and Gene Induction to Compound Structure.

Journal of biomolecular screening·2000
Same author

Cell Culture Evaluation of the Semliki Forest Virus Expression System As a Novel Approach for Antigen Delivery and Expression in Fish.

Marine biotechnology (New York, N.Y.)·2000
Same author

Campylobacter Jejuni Bacteremia in an HIV-Positive Patient With Non-Hodgkin's Lymphoma.

Cancer control : journal of the Moffitt Cancer Center·2000
Same author

IgG subclass responses to pigeon intestinal mucin in pigeon Fanciers' lung

European journal of medical research·2000

Long-term survival in medulloblastoma is possible, but early radiation therapy can cause significant intellectual impairment in young children. Avoiding or delaying radiation may improve cognitive outcomes for survivors, especially with complete tumor resection.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Radiation Oncology

Background:

  • Medulloblastoma is a common pediatric brain tumor.
  • Long-term survival rates for medulloblastoma have improved, particularly in high-risk groups.
  • Treatment, including radiation therapy, can lead to significant long-term side effects in survivors.

Purpose of the Study:

  • To evaluate the long-term neurodevelopmental outcomes of medulloblastoma survivors treated with radiation therapy at a young age.
  • To assess the impact of radiation timing and tumor resection on cognitive function in pediatric medulloblastoma survivors.
  • To investigate the incidence of endocrine dysfunction, specifically hypothyroidism, following conventional radiation therapy.

Main Methods:

  • Retrospective analysis of long-term medulloblastoma survivors.

Related Experiment Videos

  • Correlation of radiation therapy timing and dosage with neurocognitive assessments.
  • Evaluation of tumor resection status and its impact on outcomes.
  • Assessment of endocrine function, focusing on primary hypothyroidism.

    • Main Results:

    • Infants and toddlers treated with radiation therapy around age 2 experienced significant intellectual impairment.
    • Medulloblastoma survivors who had radiation therapy delayed or avoided, and achieved complete tumor resection, were more likely to attend regular school.
    • Sixty-two percent of children receiving conventional radiation therapy (mean 24 Gy) developed primary hypothyroidism.
    • Tumor markers and advanced tumor biology understanding show promise for improved surveillance.

    Conclusions:

    • Early radiation therapy for medulloblastoma in very young children is associated with severe intellectual deficits.
    • Delayed or avoided radiation therapy, coupled with complete tumor resection, may preserve cognitive function in long-term survivors.
    • Conventional radiation therapy poses a high risk of developing primary hypothyroidism.
    • Future research should focus on refining surveillance strategies using tumor markers and biological insights.