Medulloblastoma - late outcome

Long-term survivors of medulloblastoma do occur, even in high-risk groups. Infants and toddlers surviving past the age of 21 years can expect significant intellectual impairment if their radiation therapy was given at approximately 2 years of age. If radiation therapy is delayed or avoided, most of those who survive long term are in a regular school classroom. All of the latter had complete tumor resection. Sixty-two percent of children who received conventional radiation therapy (mean 24 Gy) developed primary hypothyroidism. Tumor markers and improved understanding of tumor biology may lead to more effective surveillance monitoring.