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[Membrane stabilizers (chromones and ketotifen)].
Allergie Et Immunologie
|June 17, 1999
Summary
Membrane stabilizers, including cromones and Ketotifen, effectively treat allergic conditions like asthma by inhibiting mast cell degranulation. Ketotifen also offers antihistamine benefits, making these drugs valuable for managing mild asthma and allergies.
Area of Science:
- Pharmacology
- Allergology
- Immunology
Context:
- Membrane stabilizers are a class of drugs used in allergy treatment.
- This class includes cromones (sodium cromoglycate, nedocromil) and Ketotifen.
- These drugs function by stabilizing mast cell membranes.
Purpose:
- To describe the mechanism of action of membrane stabilizers.
- To outline the current indications for these drugs.
- To evaluate their therapeutic efficacy and safety profile.
Summary:
- Membrane stabilizers inhibit mast cell degranulation via a membrane-stabilizing effect.
- Ketotifen possesses an additional antihistamine effect.
- Indications include prophylactic treatment for allergic asthma, rhinitis, conjunctivitis, and food allergies.
Impact:
- Therapeutic efficacy is noted as good for intermittent or mild persistent asthma, particularly in pediatric populations.
- Reported secondary effects are rare and generally benign.
- These drugs have a favorable safety profile with reduced contraindications.