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[Local anesthesia after percutaneous application. II].

J Ziegenmeyer, N Reuter, F R Meyer

    Archives Internationales De Pharmacodynamie Et De Therapie
    |December 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Cyclohexane and hexadecane enhance local anesthetic penetration through skin. Dimethyl sulfoxide improves anesthetic depth and duration, offering new formulation possibilities.

    Area of Science:

    • Pharmacology
    • Dermatology
    • Drug Delivery

    Context:

    • Intact skin presents a significant barrier to topical drug absorption.
    • Understanding enhancers is crucial for effective topical anesthetic delivery.

    Purpose:

    • To investigate the influence of various solvents on the skin penetration and efficacy of local anesthetics.
    • To compare the effects of different chemical enhancers on anesthetic potency and duration.

    Summary:

    • Cyclohexane and hexadecane accelerate the skin penetration of lidocaine, fomocaine, and procaine in guinea pigs.
    • Lidocaine showed the highest potency in cyclohexane, while hexadecane reduced anesthetic activity.
    • 2-butanone and dimethyl sulfoxide (DMSO) enhanced anesthetic effects, with DMSO-based anesthetic bases providing deeper, longer-lasting anesthesia compared to their salts.

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    Impact:

    • Identifies specific solvents that can significantly improve topical anesthetic efficacy.
    • Highlights the potential of DMSO as a superior vehicle for anesthetic formulations.
    • Provides insights for developing more effective transdermal drug delivery systems for local anesthetics.