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[Risperidone and concept of bipolar neuroleptic]
1Service de Psychiatrie, Hôpital Général Universitaire, Murcia, Espagne.
L'Encephale
|June 17, 1999
Summary
Risperidone exhibits stimulant properties at low doses, potentially enhancing dopaminergic transmission. This review explores its bipolar neuroleptic model, suggesting use for conditions with both depressive and psychotic symptoms.
Area of Science:
- Neuropharmacology
- Psychiatry
Context:
- Bipolar neuroleptic model proposed by Colonna and Petit (1979) categorizes drugs based on dose-dependent effects.
- Monopolar neuroleptics cause sedation, while bipolar neuroleptics show stimulant effects at low doses and sedation at high doses.
Purpose:
- To review the stimulant properties of risperidone within the framework of the bipolar neuroleptic model.
- To analyze risperidone's potential to modulate dopaminergic transmission and its clinical implications.
Summary:
- Risperidone's stimulant properties may stem from preferential presynaptic dopaminergic receptor blockade, enhancing dopaminergic transmission.
- Evidence from animal studies and clinical settings suggests risperidone can exacerbate manic symptoms and may possess antidepressant effects.
- These effects are potentially linked to its 5-HT2A and alpha 2 antagonism, leading to increased cerebral monoamines.
Impact:
- Risperidone's unique pharmacological profile suggests potential therapeutic applications.
- Highlights the possibility of using risperidone for treating complex clinical syndromes that combine depressive and psychotic features.