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Synthesis of some new biologically active thiadiazolotriazinones--Part II
B S Holla1, B K Sarojini, K Shridhara
1Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Mangalagangothri, India.
Farmaco (Societa Chimica Italiana : 1989)
|June 17, 1999
Abstract:
4-Amino-6-phenyl/methyl-3-mercapto-1,2,4-triazin-5(4H)-ones (1) are condensed with an aromatic carboxylic acid, aryloxyacetic acid or anilinoacetic acid (2), to yield 7-substituted-3-phenyl/methyl-4H-1,3,4-thiadiazolo-[2,3-c]-1,2,4-+ ++triazin-4- ones (3). Phosphorus oxychloride is used as a cyclizing agent. All the synthesized compounds are screened for their antibacterial activities against S. aureus, E. coli, P. aeruginosa and G. bacillus.