Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematopoietic commitment during embryogenesis.

S Robertson1, M Kennedy, G Keller

  • 1National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

Annals of the New York Academy of Sciences
|June 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance on the Latin American version of the Face-Name Associative Memory Exam (LAS-FNAME) distinguishes individuals with Mild Cognitive Impairment from age-matched controls in a sample from Argentina.

Applied neuropsychology. Adult·2024
Same author

S-1 maintenance therapy in Caucasian patients with metastatic esophagogastric adenocarcinoma-final results of the randomized AIO MATEO phase II trial.

ESMO open·2023
Same author

A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Fish predation and offspring survival in the prosobranch snail Viviparus ater.

Oecologia·2017
Same author

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer.

British journal of cancer·2014
Same author

Glyoxysomal citrate synthase from watermelon cotyledons: immunocytochemical localization and heterologous translation in Xenopus oocytes.

Planta·2013

Scientists identified a precursor cell capable of forming blood and blood vessel cells, supporting the hemangioblast hypothesis. This discovery advances understanding of early blood development and stem cell differentiation.

Area of Science:

  • Developmental Biology
  • Stem Cell Research
  • Hematology

Background:

  • Hematopoiesis, the formation of blood cells, originates in embryonic extraembryonic yolk sac blood islands.
  • These islands contain primitive erythrocytes and angioblasts, suggesting a shared origin.
  • The hemangioblast hypothesis proposes a common precursor for hematopoietic and endothelial cells.

Purpose of the Study:

  • To investigate the existence and potential of a common precursor for hematopoietic and endothelial cells.
  • To determine if embryonic stem (ES) cells can differentiate into such a precursor in vitro.
  • To provide in vitro evidence supporting the hemangioblast hypothesis.

Main Methods:

  • Utilizing the in vitro differentiation capacity of embryonic stem (ES) cells as a model system.

Related Experiment Videos

  • Analyzing the progeny generated from specific precursor cell populations.
  • Characterizing the hematopoietic and endothelial potential of identified precursor cells.

    • Main Results:

    • A precursor cell population was identified with the capacity to generate both endothelial cells and hematopoietic cells (primitive and definitive).
    • The developmental potential of this precursor aligns with the predicted characteristics of the hemangioblast.
    • This finding was achieved using an in vitro differentiation model derived from ES cells.

    Conclusions:

    • The identified precursor cell population represents the in vitro equivalent of the hemangioblast.
    • This study provides experimental evidence supporting the hemangioblast hypothesis.
    • The findings contribute to a deeper understanding of early hematopoiesis and endothelial development from a common progenitor.