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[Thrombospondins, tumor angiogenesis and breast cancer]
P Clézardin1, G Bruno-Bossio, A Fontana
1INSERM Unité 403, Faculté de Médecine Laënnec, Lyon, France.
Pathologie-Biologie
|June 18, 1999
Abstract:
Thrombospondin-1 and -2 are extracellular matrix proteins that are overexpressed in breast cancer tissue. Their role in breast cancer remains unknown. This article reviews the potential effects of thrombospondin-1 and -2 in breast cancer tumori genesis and metastatic dissemination.