[VEGF in therapeutic coronary and peripheral artery angiogenesis]

An overview is presented of the various steps of angiogenesis, to which an important contributor is Vascular Endothelial Growth Factor (VEGF), a substance capable of increasing both the permeability and the mitosis rate of endothelial cells. VEGF is also a potent vasodilating agent. The beneficial effects of these properties on the ischemic vasculature have been documented in numerous animal models, leading to the concept of angiogenesis-enhancement as a therapeutic tool. The first clinical trials are under way. This area is discussed based on a literature review.