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Updated: Aug 9, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
[Potential impact of measures to minimize drug costs in Aragon's primary care system]
M Siles Gutiérrez1, F J García Latorre, J M Abad Díez
1Direcciones Provinciales del INSALUD de Zaragoza, Huesca y Teruel. zrdpif@insalud.es
Objective:
To analyse the potential saving in pharmaceutical expenditure which the use of drug products of the same composition and lower price would suppose, by three high-consumption therapeutic sub-groups.
Design:
Retrospective observation study.
Setting:
Primary care.
Participants:
All the medical prescriptions of the doctors in the 121 primary care health districts in the three provinces of the Autonomous Community of Aragon during 1997, divided into the sub-groups: peptic ulcer (AO2B), lipid-lowering (B04A) and hypotensor drugs (C02).
Measurements And Main Results:
Consumption, cost of treatment per day and potential saving of eight active principles belonging to these 3 sub-groups were calculated. Potential overall saving reached the figure of 972 million pesetas in Aragon in 1997.
Conclusions:
The alternative of prescribing drugs with an identical composition and lower price offers great potential savings in pharmaceutical expenditure, and may be a useful measure to improve the efficiency of health resources, and in particular those devoted to drug prescription.
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