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Behavioural and hormonal differences between two Lewis rat lines.

T Stöhr1, T Szuran, V Pliska

  • 1Behavioural Biology Laboratory, Swiss Federal Institute of Technology, Zurich.

Behavioural Brain Research
|June 18, 1999
PubMed
Summary
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Two Lewis rat sublines exhibit distinct behavioral responses to stress and amphetamine, with subtle differences in the hypothalamus-pituitary-adrenal (HPA) system. These findings highlight genetic variations within inbred rat models.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Immunology

Background:

  • Lewis (LEW) rats are a common model for autoimmune diseases.
  • Variations exist in autoimmune disease susceptibility among LEW rat lines.
  • The hypothalamus-pituitary-adrenal (HPA) system is implicated in autoimmune disease pathophysiology.

Purpose of the Study:

  • To compare behavioral and neuroendocrine stress responses in two LEW rat sublines (SsNHsd and HANRijHsd).
  • To investigate the psychostimulant effects of amphetamine in these sublines.

Main Methods:

  • Behavioral testing: open field test, acoustic startle response, prepulse inhibition, active avoidance learning.
  • Neuroendocrine assessment: serum corticosterone levels.
  • Pharmacological manipulation: acute and repeated amphetamine administration.

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Main Results:

  • HAN rats displayed reduced activity, faster habituation, lower startle response, and greater prepulse inhibition compared to SSN rats.
  • HAN rats showed impaired active avoidance learning and smaller acute psychostimulant effects of amphetamine.
  • Behavioral sensitization to amphetamine was more pronounced in HAN rats after repeated administration.
  • Basal corticosterone levels were similar, but HAN rats had slightly higher corticosterone secretion post-stress.

Conclusions:

  • Significant behavioral differences exist between HAN and SSN LEW rat sublines.
  • These behavioral variations are only minimally reflected in HPA system activity.
  • Further research is needed to understand the implications of these subline differences for autoimmune disease modeling.