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Uveitis associated with varicella virus vaccine
B Esmaeli-Gutstein1, J Z Winkelman
1Ophthalmology Section, M.D. Anderson Cancer Center, Houston, Texas 77030-4095, USA. bgutstein@mdanderson.org
American Journal of Ophthalmology
|June 18, 1999
Summary
A rare case of uveitis, an inflammatory eye condition, occurred in a child after receiving the live attenuated varicella virus vaccine (Varivax). This adverse event highlights the importance of recognizing potential side effects of the varicella vaccine.
Area of Science:
- Ophthalmology
- Vaccinology
- Immunology
Background:
- The live attenuated varicella virus vaccine (Varivax) is widely used for preventing chickenpox.
- Adverse events following vaccination are closely monitored to ensure vaccine safety.
Observation:
- A young, healthy female patient developed uveitis shortly after varicella vaccination.
- The uveitis was characterized by specific onset timing and vesicular rash patterns post-vaccination.
Findings:
- The patient's uveitis and rash resolved effectively with standard treatment including oral acyclovir and topical corticosteroids.
- A comprehensive literature review and manufacturer communication revealed no previously documented cases of uveitis linked to Varivax.
Implications:
- This case suggests uveitis may be a potential, albeit rare, adverse effect of the varicella vaccine.
- Ophthalmologists and pediatricians should consider vaccine-associated uveitis in differential diagnoses for similar presentations.