Related Experiment Video
Updated: Aug 11, 2026
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Comparison between semiquantitative interictal Tc-99m HMPAO SPECT and clinical parameters in children with partial
A Sarikaya1, M Kaya, S Karasalihoglu
1Department of Nuclear Medicine, Trakya Universitesi Tip Fakültesi, Edirne, Turkey.
Insights
This study found correlations between clinical seizure characteristics and SPECT scan findings in children with partial seizures. Higher seizure frequency was linked to more significant hypoperfusion on SPECT imaging.
Area of Science:
- Neurology
- Medical Imaging
- Pediatrics
Background:
- Partial seizures in children can be challenging to diagnose and manage.
- Interictal SPECT imaging is a tool used to identify brain regions with reduced blood flow.
- Understanding the relationship between clinical features and imaging findings is crucial for effective treatment.
Purpose of the Study:
- To investigate the correlation between clinical parameters and semiquantitative interictal SPECT findings in pediatric patients with partial seizures.
- To determine if SPECT parameters can be used to assess seizure characteristics.
Main Methods:
- Retrospective analysis of 30 pediatric patients with partial seizures and hypoperfusion on interictal SPECT.
- Clinical data including age, age of seizure onset, frequency, and duration were collected.
- SPECT studies were evaluated visually and quantitatively using asymmetry index (AI) and number of regions of interest (ROIs) for hypoperfusion.
Main Results:
- Visual analysis revealed ipsilateral hypoperfusion in 76% of patients.
- An inverse correlation was found between age at seizure onset and AI (r = -0.40, P = 0.025).
- A positive correlation was observed between seizure frequency and AI (r = 0.77, P = 0.000) and number of ROIs (r = 0.67, P = 0.000).
Conclusions:
- Semiquantitative SPECT parameters correlate with clinical parameters in pediatric partial seizures.
- Seizure frequency and age at onset are associated with the degree and extent of hypoperfusion on SPECT.
- SPECT imaging may serve as a valuable tool for correlating clinical and imaging findings in pediatric epilepsy.
Abstract:
The aim of the present study was to correlate between clinical parameters (age, age of onset, frequency and duration of seizures) and semiquantitative interictal SPECT parameters in children with partial seizures. We obtained 30 patients who had hypoperfusion in interictal SPECT, retrospectively. All patients underwent a detailed clinical examination, electroencephalography (EEG) investigation and brain computerized tomography (CT) and/or magnetic resonance imaging (MRI). Single photon emission computerized tomography (SPECT) studies were evaluated visually and by calculating semiquantitative parameters (the degree (asymmetry index, AI) and extent (number of ROI) of hypoperfusion). Visual analysis detected ipsilateral hypoperfusion in 23 (76%) patients with a unilateral focus and contralateral hypoperfusion in seven patients. We found an inverse correlation between the age at onset of seizure (r = -0.40, P = 0.025), frequency of seizures(but positive correlation; r = 0.77, P = 0.000) and AI. Number of ROIs showed a moderate correlation with the frequency of seizures (r = 0.67, P = 0.000), while correlation of the age at onset of seizures was not significant. This study performed in pediatric patients also suggested that either SPECT parameters may be used for correlating with clinical parameters.
More Related Videos
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
09:57Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024