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Related Experiment Videos

Plastic migration from implanted central venous access devices.

P A Dewan1, S K Condron, P N Morreau

  • 1Department of General Surgery, Royal Children's Hospital, Melbourne, Australia. dewan@cryptic.rch.unimelb.edu.au

Archives of Disease in Childhood
|June 18, 1999
PubMed
Summary
This summary is machine-generated.

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Foreign material, including silicone, can migrate from intravenous access devices in children. Histological examination of tissue capsules revealed foreign body responses and elemental silicon in several samples.

Area of Science:

  • Pediatric medicine
  • Biomaterials science
  • Histopathology

Background:

  • First study reporting histological evidence of migration from pediatric intravenous access devices.
  • Intravenous access devices are commonly used in children for medication delivery and fluid management.

Purpose of the Study:

  • To investigate the presence and nature of foreign material within the capsules surrounding pediatric intravenous access devices.
  • To determine the extent of the foreign body response to implanted devices.

Main Methods:

  • Capsules from around intravenous access devices were analyzed using light microscopy.
  • Energy-dispersive X-ray analysis was employed to identify elemental composition of foreign material.

Main Results:

Related Experiment Videos

  • Fibroconnective tissue capsules were consistently found around all examined intravenous access device samples.
  • Elemental silicon was detected in 6 of 13 tissue samples.
  • A foreign body giant cell reaction was observed in 3 samples with detected silicon.

Conclusions:

  • The pseudocapsule surrounding implanted vascular access devices frequently contains residual foreign material.
  • Silicone is a common component of this foreign material found in pediatric patients.