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Related Experiment Videos

Enhanced blood pressure variability in eNOS knockout mice.

H M Stauss1, A Gödecke, R Mrowka

  • 1Institute of Physiology, Humboldt University (Charité), Berlin, Germany. harald.stauss@rz.hu-berlin.de

Hypertension (Dallas, Tex. : 1979)
|June 18, 1999
PubMed
Summary

Endogenous nitric oxide buffers blood pressure variability. Studies show the endothelial nitric oxide synthase isoform is key in regulating blood pressure oscillations in mice.

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Area of Science:

  • Cardiovascular Physiology
  • Nitric Oxide Signaling

Background:

  • Endogenous nitric oxide (NO) is known to buffer arterial blood pressure variability.
  • Previous studies blocking all nitric oxide synthase (NOS) isoforms showed increased blood pressure variability.
  • The specific NOS isoform responsible for this buffering effect remained unclear.

Purpose of the Study:

  • To determine which nitric oxide synthase (NOS) isoform mediates the blood pressure buffering effect of endogenous nitric oxide.
  • To compare blood pressure variability in mice lacking endothelial NOS (eNOS) with wild-type controls.

Main Methods:

  • Utilized knockout mice lacking the gene for endothelial nitric oxide synthase (eNOS).
  • Recorded arterial blood pressure in conscious mice following carotid artery cannulation.

Related Experiment Videos

  • Analyzed blood pressure variability using power spectral analysis at low frequencies (0.05–0.40 Hz).

    • Main Results:

    • Blood pressure variability was significantly enhanced in eNOS knockout mice compared to wild-type controls (10.5 vs. 6.0 mm Hg²).
    • The increase in blood pressure variability was primarily observed at low frequencies (0.05–0.40 Hz).
    • eNOS knockout mice showed higher variability at low frequencies (5.1 vs. 2.5 mm Hg²).

    Conclusions:

    • The blood pressure buffering effect of endogenous nitric oxide is mediated by the endothelial isoform of nitric oxide synthase (eNOS).
    • Endothelial nitric oxide plays a crucial role in stabilizing blood pressure oscillations, particularly within the low-frequency range of 0.05–0.40 Hz in conscious mice.