Genetic models in pharmacology: present status and future

Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine.

Proceedings of the National Academy of Sciences of the United States of America·2022

The physiological relevance of functional selectivity in dopamine signalling.

International journal of obesity supplements·2016

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Molecular psychiatry·2015

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Neurobiology of disease·2014

Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.

British journal of pharmacology·2013

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

The Journal of pharmacology and experimental therapeutics·2013

Reversing Antibiotic Resistance and Reprogramming Macrophage Polarization by Extracellular Vesicles from Fresh Schisandra chinensis: A Dual Pharmacological Strategy for Drug-Resistant Wound Infection and Sepsis.

Pharmacological research·2026

A universal cell-based method for high-throughput analysis of viroporin function and inhibition.

Pharmacological research·2026

Prospective Associations of Tea Consumption with Skeletal Muscle Mass and Strength: Insights from the Gut Microbiome and Proteomics.

Pharmacological research·2026

GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors.

Pharmacological research·2026

Disarming cGAS-STING hyperactivation in autoimmune and inflammatory diseases: Pathogenic mechanisms and emerging therapeutic strategies.

Pharmacological research·2026

Oncolytic Virus-Delivered CEACAM6/CD3 BiTEs Combine with PD-1 Blockade to Achieve Synergistic Anticancer Efficacy.

Pharmacological research·2026

Clinical and Molecular Findings in Two Siblings with a Novel Homozygous DCAF17 Frameshift Variant and Review of the Literature: A Case Report.

Molecular syndromology·2026

Integrative methylome and transcriptome analysis reveals genotype and sequence context-specific responses to aluminum stress in rice.

Frontiers in plant science·2026

AdaBoost-based differential diagnosis of gouty arthritis and rheumatoid arthritis: model construction, temporal validation, and SHAP visualization.

Frontiers in medicine·2026

Refining genetic discoveries of group knockoffs via a feature-level filter.

Journal of the Royal Statistical Society. Series C, Applied statistics·2026

Spatial decoupling of plaque and circulating immune programs defines a robust gene signature in atherosclerosis: A multi-cohort integrative analysis.

Medicine·2026

Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study.

Medicine·2026

Related Experiment Videos

Genetic models in pharmacology: present status and future

Related Concept Videos

Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine.

The physiological relevance of functional selectivity in dopamine signalling.

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

Reversing Antibiotic Resistance and Reprogramming Macrophage Polarization by Extracellular Vesicles from Fresh Schisandra chinensis: A Dual Pharmacological Strategy for Drug-Resistant Wound Infection and Sepsis.

A universal cell-based method for high-throughput analysis of viroporin function and inhibition.

Prospective Associations of Tea Consumption with Skeletal Muscle Mass and Strength: Insights from the Gut Microbiome and Proteomics.

GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors.

Disarming cGAS-STING hyperactivation in autoimmune and inflammatory diseases: Pathogenic mechanisms and emerging therapeutic strategies.

Oncolytic Virus-Delivered CEACAM6/CD3 BiTEs Combine with PD-1 Blockade to Achieve Synergistic Anticancer Efficacy.

Clinical and Molecular Findings in Two Siblings with a Novel Homozygous DCAF17 Frameshift Variant and Review of the Literature: A Case Report.

Integrative methylome and transcriptome analysis reveals genotype and sequence context-specific responses to aluminum stress in rice.

AdaBoost-based differential diagnosis of gouty arthritis and rheumatoid arthritis: model construction, temporal validation, and SHAP visualization.

Refining genetic discoveries of group knockoffs via a feature-level filter.

Spatial decoupling of plaque and circulating immune programs defines a robust gene signature in atherosclerosis: A multi-cohort integrative analysis.

Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study.

Related Experiment Videos

Genetic models in pharmacology: present status and future

Related Concept Videos

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