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[Relationship between p16 and Rb protein expression in astrocytomas]
Objective:
p16 and Rb protein were examined in primary astrocytomas in order to study the correlation between p16 and Rb proteins.
Methods:
p16 and Rb pretoin were immunostained by SP immunohistochemical method in the sections of formalin fixed paraffin embedded tumor tissue from 102 patients with astrocytoma brain tumors.
Results:
p16 and Rb protein were expressed in all low grade (WHO Grade I and II) astrocytomas but only in 48.1% and 57.4% astrocytomas of Grade III and Grade IV respectively, in which, 24/31 of Rb protein positive tumors showed null or low expression of p16 protein, while 19/23 of Rb negative tumors were associated with positive or high level expression of p16 protein.
Conclusions:
(a) p16 and Rb proteins were both involved in astrocytoma progression. (b) Negatively correlated pressionof p16 and Rb protein might be one of characteristics of malignant astrocytoma.