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Primary Sjögren's syndrome and its lymphoid malignancy: a report of four cases
1Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Chinese Medical Journal
|June 22, 1999
Abstract
Objective:
To evaluate the incidence and spectrum of malignancy of primary Sjögren's syndrome (pSS).
Methods:
250 pSS who were followed-up in Peking Union Medical College (PUMC) Hospital were analyzed.
Results:
Four of them were diagnosed with histopathological findings of 2 non-Hodgkin Lymphoma, 1 AILD, 1 multiple myeloma. Two died of secondary infection while receiving chemotherapy for lymphoma, 2 remained remitted.
Conclusions:
The risk factors were persistent enlargement of major salivary glands, appearance of monoclonal serum lg, and disappearance of auto antibodies.